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Reishi polysaccharides cut the SARS-CoV-2 number in animal lungs
2021-02-01   Source:    Hit:242   Font: 

 

Does Ganoderma lucidum (also called Reishi or Lingzhi) have an inhibitory effect on the novel coronavirus (SARS-CoV-2)? Does eating Ganoderma lucidum after getting infected with the 2019 novel coronavirus pneumonia (COVID‐19) help to suppress the novel coronavirus?

 

We have always used the immune regulation function of Ganoderma lucidum as the theoretical basis of Ganoderma lucidum in anti-virus. Now, there is finally direct evidence to provide us with a clear answer.

 

A report published by the Taiwanese research team in PNAS (Proceedings of the National Academy of Sciences) on January 15 this year (2021) confirmed that Ganoderma lucidum polysaccharides, one of the main active ingredients in Ganoderma lucidum, can inhibit the infection of cells by the novel coronavirus, inhibit the replication and proliferation of the novel coronavirus in the cells, and reduce the number of the novel coronavirus in the lungs after animals are infected with the novel coronavirus.

 

Inhibition of virus replication without harming cells

 

The above-mentioned research team first conducted in vitro experiments: first, Vero E6 cells and the Ganoderma lucidum polysaccharide extract (code name as RF3) were cultured together, and then the novel coronavirus was added to observe the number of virus replication and cell survival after 48 hours.

 

As we all know, the novel coronavirus invades the human body through the ACE2 receptor on the cell. Vero E6 cells from the kidney tissue of African green monkeys can express a large number of ACE2 receptors, so when they come into contact with the novel coronavirus, the novel coronavirus can easily enter these cells to replicate and proliferate.

 

The results show that the Ganoderma lucidum polysaccharide extract can reduce the amount of virus replication to half at a low concentration of 2 μg/mL without causing cell death (see the picture and text taken from the research report below for details).

 

 

Reduction of the amount of virus in the lungs of hamsters

 

The next step was animal experiments: hamsters were first infected with the novel coronavirus, and then the Ganoderma lucidum polysaccharide extract was administered to these hamsters orally at a daily dose of 200 mg/kg for 3 days.

 

It was found that the amount of virus in the lungs of hamsters was only about half of the control group (without any drugs) (as shown in the figure below), and the weight of hamsters did not drop significantly. This means that the Ganoderma lucidum polysaccharide extract can not only effectively inhibit the proliferation of the novel coronavirus but also is highly safe to eat.

 

 

 


Don't underestimate the results of the "hamster" experiment. The respiratory tissues of hamsters are similar to those of humans. When the immune system is stimulated by infection, the respiratory tissues of hamsters also have inflammatory cytokines similar to those of humans. Therefore, the results of the struggle between the Ganoderma lucidum polysaccharide extract and the new coronavirus in hamsters have considerable reference value.

 

Ganoderma lucidum polysaccharides stand out from over 3,000 drugs and extracts

 

The above experiments have shown us that Ganoderma lucidum polysaccharides can protect cells and fight against novel coronavirus infections - at least when taken before infection or during the initial stage of infection, Ganoderma lucidum polysaccharides do have a very good antiviral effect.

 

It is really not simple that Ganoderma lucidum polysaccharides can stand out in this research.

 

The research team first collected 2,855 human or animal medicines approved by the U.S. Food and Drug Administration (FDA). Second, the team selected nearly 200 medicinal materials with curative effects on viral infections from the classics of traditional Chinese herbal medicine. Next, the team screened out 15 drugs or ingredients with potential against viral infections in cell experiments conducted in the P3 laboratory.

 

The team then winnowed the top 7 drugs or ingredients into animal experiments to go head to head with the virus strains. In the end, only 2 kinds of drugs (the anti-malaria drug called mefloquine and the anti-AIDS drug called nelfinavir) and 3 kinds of herbal medicines and herbal extracts (Ganoderma lucidum polysaccharides, Perilla frutescens and Mentha haplocalyx) can really exert antiviral effects in the body.

 

Among these five ingredients, only Ganoderma lucidum polysaccharides can be effective against viruses without causing cell death, weight loss or affecting body functions.

 

Moreover, polysaccharides are only one of the active ingredients in Ganoderma lucidum. If we can add triterpenes or use the whole Ganoderma lucidum to fight the virus, what will happen?

 

Vaccines can only protect one part of our body, but what should be used to protect the part that vaccines cannot protect?

 

Let's eat more Ganoderma lucidum!

 

And it must be Ganoderma lucidum that has undergone standardized organic cultivation, extraction and processing, has complete active ingredients, and has health food approvals. Only such Ganoderma lucidum will not let you down.

 

【Data Source】

Jia-Tsrong Jan, et al. Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection. PNAS. 2021, 118 (5) e2021579118 ; https://doi.org/10.1073/pnas.2021579118.

 

END

 

About the author/ Ms. Wu Tingyao

Wu Tingyao has been reporting on first-hand Ganoderma lucidum information since 1999. She is the author of Healing with Ganoderma (published in The People's Medical Publishing House in April 2017). 

 

 

★ This article is published under the exclusive authorization of the author, and the ownership belongs to GANOHERB ★ The above works cannot be reproduced, excerpted or used in other ways without the authorization of GanoHerb ★ If the works have been authorized to be used, they should be used within the scope of authorization and indicate the source: GanoHerb ★ Violation of the above statement, GanoHerb will pursue its related legal responsibilities ★ The original text of this article was written in Chinese by Wu Tingyao and translated into English by Alfred Liu. If there is any discrepancy between the translation (English) and the original (Chinese), the original Chinese shall prevail. If readers have any questions, please contact the original author, Ms. Wu Tingyao.

 

 

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